The partnership in between the endocannabinoid technique (ECS) and bone density regulation is effectively established, but there is quite small investigation on the efficacy of cannabis in the remedy of osteoporosis.
In reality, proof suggests that cannabis could harm bone development.
The Endocannabinoid System’s Function in Regulating Bone Density
Just before cannabis was particularly identified as a prospective trigger of osteoporosis, researchers found that the ECS played a function in the onset of the illness.
A 2005 All-natural Medicine study determined that the activation of CB1 receptors played a function in decreasing bone mass and ovariectomy induced bone loss in mice. This partnership led the researchers to recommend in the study that “recreational or therapeutic use of cannabis derivatives…might boost bone loss and predispose to osteoporosis.”
Whilst the influence of the ECS is getting studied, according to Dr. Tiab and investigation, the very best approaches to avert osteoporosis are:
- A diet regime plentiful in calcium
- Vitamin D
- Weight-bearing workout
- Cigarette avoidance
Targeting CB2 Receptors Could Slow Osteoporosis
That getting mentioned, in a 2017 critique, researchers showed when targeting certain cannabinoid receptors (CB2), they have been in a position to slow osteoporosis and lessen bone discomfort.
The authors of the critique urged for the continued study of certain cannabinoids to determine which ones could safely target CB2 receptors.
CBD Could Decrease Bone Loss
A 2017 European Journal of Pharmacology study analyzed the impact of CBD on the loss of BMD in rats. The rats’ spines have been surgically impaired and then treated with CBD for the following 14 days.
The outcomes have been promising: CBD improved the production of bone forming agents and enhanced the quantity and high quality of bone tissue in the spine.
The researchers determined that CBD had effectively treated spinal cord injury induced bone loss in an animal model.
A lot more investigation will require to be carried out to realize how this translates to human sufferers.
Proof Implicating Cannabis in the Onset of Osteoporosis is Weak
In 2009, a BMJ Case Reports released a study by professor Albert Reese implicated heavy cannabis use in the exacerbation of multi-organ cystic illness, a situation characterized by the progression of many ailments which trigger cysts to create all through the physique.
The study examined one particular patient, a 56-year-old man who demonstrated lethargy and a low tolerance for workout. The man consumed up to six tobacco cigarettes a day, up to 7 grams of cannabis a day, and substantial quantities of hashish oil.
He reported consuming cannabis from the age of 22 to 47. The man was located to have dozens of cysts in the lungs and bone density levels falling in the osteoporotic variety. The researchers concluded that his extreme situation was the outcome of multi-organ cystic illness “exacerbated by the smoking of tobacco, cannabis, and asthma.”
Even though Reese’s study presents apparently damning proof against cannabis, it is problematic for many causes.
Correlation does not equal causation
Very first, the study does not adequately deal with the causation.
It is unclear regardless of whether the man created cysts and suffered bone loss for the reason that he consumed a lot of weed or if he consumed a lot of weed for the reason that of his particularly uncomfortable physical symptoms.
Cannabis has been identified to possess bronchodilation and discomfort-relieving qualities, so it is probable that the patient was consuming substantial quantities of marijuana for the reason that the plant alleviated his symptoms.
Also, Reese blames cannabis for the man’s deteriorating dental wellness, citing a craving for sweets whilst higher. Nevertheless, the report does not describe the man’s dental wellness regimen.
If the patient ate a substantial quantity of sweets but consistently flossed and brushed his teeth, periodontal illness may well not be apparent. Sadly, we do not know the man’s oral hygiene routine for the reason that that details is missing from the study.
A 2017 Archives of Osteoporosis study introduced added doubt to the thought that cannabis is accountable for osteoporosis.
The study gathered information from a national survey of persons aged 20 to 59 years old, to figure out the partnership in between former, light, and heavy cannabis use and decreased bone mineral density (BMD) of the hip or spine.
The researchers concluded they could not locate a correlation in between a history of cannabis use and BMD.
Diet regime and workout is a lot more verified to impact bone wellness
A different 2017 study by Dr. Antonia Sophocleous presented restricted proof associating cannabis with low bone mineral density. Researchers located that the improved danger of fractures and lowered bone density was an indirect symptom of heavy cannabis use due to low BMI.
That is, cannabis use may well lessen BMI, and lowered BMI may well be linked with lowered BMD. Whilst this American Journal of Medicine study could not supply robust causal proof linking cannabis use to decreased bone density, it did make two significant observations.
Very first, Sophocleous’ investigation does appear to show a hyperlink in between cannabinoids and the body’s potential to conduct bone resorption. Bones are in a continuous state of growth—bone cells named osteoclasts generally recycle themselves to market bone development.
But most importantly, Sophocleous’ outcomes are a reminder that taking care of your physique by working out and consuming wholesome foods is an helpful way to mitigate the danger of creating osteoporosis later in life.
For now, this suggests that pot smokers really should continue to retain an active life style and nutritious diet regime whilst remaining cautious about the influence their cannabis use can have on their bones.
This details is presented for educational purposes only, and is not intended to diagnose, treat, remedy or avert any health-related situation. Please generally seek advice from your personal medical professional.